99th Monkey
Menu

crossroads blog

Components of mRNA Technology “Could Lead to Significant Adverse Events in One or More of Our Clinical Trials,” says Moderna

19/11/2020

0 Comments

 
By Children's Health Defense Team

6th August 2020

Picture
As the race to find a vaccine gathers pace, this report from "Children's Health Defence" highlights some of the challenges involved.
Summary:
  • mRNA vaccines undergoing Covid-19 clinical trials, including the Moderna vaccine, rely on a nanoparticle-based “carrier system” containing a synthetic chemical called polyethylene glycol (PEG).
  • The use of PEG in drugs and vaccines is increasingly controversial due to the well-documented incidence of adverse PEG-related immune reactions, including life-threatening anaphylaxis.
  • Roughly seven in ten Americans may already be sensitized to PEG, which may result in reduced efficacy of the vaccine and an increase in adverse side effects.
  • If a PEG-containing mRNA vaccine for Covid-19 gains FDA approval, the uptick in exposure to PEG will be unprecedented—and potentially disastrous.
  • Moderna documents and publications indicate that the company is well aware of safety risks associated with PEG and other aspects of its mRNA technology but is more concerned with its bottom line.
A dozen Covid-19 vaccines are undergoing clinical trials, leading a crowded field that now numbers approximately 170 candidates. Several of the U.S. contenders—Moderna, Pfizer/BioNTech and Arcturus Therapeutics—are deploying never-before-approved messenger RNA (mRNA) technology, an experimental approach designed to turn the body’s cells into viral-protein-making factories.

A key technical challenge is to get the vaccines’ bulky RNA “payload” into the cells intact—without it breaking down prior to arriving at its destination. In other words, mRNA vaccines will not work without an in-built delivery mechanism that enables the mRNA to shove its way into a cell’s cytoplasm. The chosen solution is to use trendy biotech “carrier systems” involving lipid nanoparticles (LNPs). LNPs “encapsulate the mRNA constructs to protect them from degradation and promote cellular uptake” and, additionally, rev up the immune system (a property that vaccine scientists tamely describe as LNPs’ “inherent adjuvant properties”). The LNP formulations in the three Covid-19 vaccines are also “PEGylated,” meaning that the vaccine nanoparticles are coated with a synthetic, nondegradable and increasingly controversial polymer called polyethylene glycol (PEG).

Read more here . . .

0 Comments



Leave a Reply.

    Crossroads blog

    The random thoughts of 99th Monkey . . . an occasional rant and other reflections in the hall of mirrors.

    Archives

    October 2023
    September 2023
    August 2023
    July 2023
    June 2023
    May 2023
    April 2023
    March 2023
    February 2023
    January 2023
    December 2022
    November 2022
    October 2022
    September 2022
    August 2022
    July 2022
    June 2022
    May 2022
    April 2022
    March 2022
    February 2022
    January 2022
    December 2021
    November 2021
    October 2021
    September 2021
    August 2021
    July 2021
    June 2021
    May 2021
    April 2021
    March 2021
    February 2021
    January 2021
    December 2020
    November 2020
    October 2020
    September 2020
    August 2020
    July 2020
    June 2020
    May 2020

    Categories

    All

    RSS Feed

  • Home
  • About
  • Latest 99M Music
  • 1998 - 2018
  • 1986 - 1987
  • 1983 - 1985
  • 1975 - 1982
  • Down Home Blues Band
  • doublevision
  • Others
  • Crossroads blog
  • Contact
  • Home
  • About
  • Latest 99M Music
  • 1998 - 2018
  • 1986 - 1987
  • 1983 - 1985
  • 1975 - 1982
  • Down Home Blues Band
  • doublevision
  • Others
  • Crossroads blog
  • Contact